Welcome to Chillicothe, MO, a rural agricultural community in North Central Missouri that sits at the intersection of U.S. Highways 36 & 65. Our historic Main Street is the heart of this charming town. It features many shops and restaurants for your enjoyment as you walk around the square. If you are looking for fun activities, Chillicothe offers bowling, roller skating, movie theater, water park, and other seasonal activities!
The north end of town is the home of the newer Chillicothe Hornets High School and the recently completed Chillicothe Elementary School. Another option for schooling is Bishop Hogan Memorial School which is centrally located and a great option for private schooling. Conveniently located at the corner of US 36 and Hwy 190 is Hedrick Medical Center, a state-of-the-art St. Luke’s Health system facility which was newly built and opened in February 2014. Our real estate market stays steady throughout the year with houses offered at a varied price range. We are a proud, supportive community and hope you will consider becoming a part of it!